AccScience Publishing / STI / Online First / DOI: 10.36922/STI026240028
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REVIEW ARTICLE

Contemporary surgical management of cervical cancer: Minimally invasive surgery, de-escalation and personalized approaches

Simone Ferrero1,2* Valerio Gaetano Vellone3,4 Francesco Paolo Rosato1 Elena Chitoran5,6 Rosa Alba Pugliesi7 Giuseppe Gullo8 Fabio Barra1
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1 Azienda Ospedaliera Metropolitana (AOM), Genova, Italy
2 Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), School of Medical and Pharmaceutical Sciences, University of Genova, Genova, Italy
3 Pathology Unit, IRCCS-Istituto Giannina Gaslini, Genoa, Italy
4 Section of Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), School of Medical and Pharmaceutical Sciences, University of Genova, Genoa, Italy
5 Department of General Surgery, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
6 General Surgery and Surgical Oncology Department I, Bucharest Institute of Oncology “Prof. Dr. Alexandru Trestioreanu,” Bucharest, Romania
7 Section of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), School of Medicine and Surgery, University of Palermo, Palermo, Italy
8 Unit of Obstetrics and Gynecology, AOOR Villa Sofia Cervello, University of Palermo, Palermo, Italy
Received: 14 June 2026 | Revised: 13 August 2026 | Accepted: 17 August 2026 | Published online: 28 August 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Cervical cancer is one of the most common gynecologic malignancies worldwide, with radical hysterectomy representing the cornerstone of surgical management for early-stage disease. The past decade has witnessed profound shifts in the surgical paradigm, driven primarily by the LACC trial, which demonstrated significantly inferior disease-free survival with minimally invasive surgery (MIS) compared to open radical hysterectomy. Subsequent analyses, including the SUCCOR study, implicated uterine manipulator use and unprotected colpotomy as important technical factors associated with occurrence, suggesting that operative technique may have contributed to the inferior oncologic outcomes observed after MIS. Concurrently, evolving evidence has supported surgical de-escalation strategies in carefully selected patients: the SHAPE trial established the non-inferiority of simple hysterectomy compared with radical hysterectomy in low-risk stage IB1 disease, while fertility-sparing approaches (including radical trachelectomy and large-cone excision) continue to gain acceptance among young women with early-stage tumors. Sentinel lymph node biopsy has emerged as a validated, lower-morbidity alternative to systematic pelvic lymphadenectomy. The integration of tumor biology, imaging, and molecular profiling is increasingly guiding personalized surgical planning, with particular attention to histologic subtype and lymphovascular space invasion status. This review critically examines the current evidence for MIS, de-escalation, and individualized surgical strategies in cervical cancer, synthesizing data from randomized trials, prospective registries, and meta-analyses to provide a comprehensive framework for contemporary clinical decision-making.

Keywords
Cervical cancer
Radical hysterectomy
Minimally invasive surgery
Surgical de-escalation
Sentinel lymph node biopsy
Fertility-sparing surgery
Personalized surgery
Funding
None.
Conflict of interest
The authors declare they have no competing interests.
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Surgical Technology International, Electronic ISSN: 1090-3941 Published by AccScience Publishing