Contemporary surgical management of cervical cancer: Minimally invasive surgery, de-escalation and personalized approaches
Cervical cancer is one of the most common gynecologic malignancies worldwide, with radical hysterectomy representing the cornerstone of surgical management for early-stage disease. The past decade has witnessed profound shifts in the surgical paradigm, driven primarily by the LACC trial, which demonstrated significantly inferior disease-free survival with minimally invasive surgery (MIS) compared to open radical hysterectomy. Subsequent analyses, including the SUCCOR study, implicated uterine manipulator use and unprotected colpotomy as important technical factors associated with occurrence, suggesting that operative technique may have contributed to the inferior oncologic outcomes observed after MIS. Concurrently, evolving evidence has supported surgical de-escalation strategies in carefully selected patients: the SHAPE trial established the non-inferiority of simple hysterectomy compared with radical hysterectomy in low-risk stage IB1 disease, while fertility-sparing approaches (including radical trachelectomy and large-cone excision) continue to gain acceptance among young women with early-stage tumors. Sentinel lymph node biopsy has emerged as a validated, lower-morbidity alternative to systematic pelvic lymphadenectomy. The integration of tumor biology, imaging, and molecular profiling is increasingly guiding personalized surgical planning, with particular attention to histologic subtype and lymphovascular space invasion status. This review critically examines the current evidence for MIS, de-escalation, and individualized surgical strategies in cervical cancer, synthesizing data from randomized trials, prospective registries, and meta-analyses to provide a comprehensive framework for contemporary clinical decision-making.
- Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263. doi: 10.3322/caac.21834
- Landoni F, Maneo A, Colombo A, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997;350(9077):535-540. doi: 10.1016/S0140-6736(97)02250-2
- Bizzarri N, Querleu D, Dostalek L, et al. Survival associated with extent of radical hysterectomy in early-stage cervical cancer: a subanalysis of the Surveillance in Cervical CANcer (SCCAN) collaborative study. Am J Obstet Gynecol. 2023;229(4):428.e1-428.e12. doi: 10.1016/j.ajog.2023.06.030
- Shazly SA, Murad MH, Dowdy SC, Gostout BS, Famuyide AO. Robotic radical hysterectomy in early stage cervical cancer: A systematic review and meta-analysis. Gynecol Oncol. 2015;138(2):457-471. doi: 10.1016/j.ygyno.2015.06.009
- Nezhat CR, Burrell MO, Nezhat FR, Benigno BB, Welander CE. Laparoscopic radical hysterectomy with paraaortic and pelvic node dissection. Am J Obstet Gynecol. 1992;166(3):864-865. doi: 10.1016/0002-9378(92)91351-a
- Pomel C, Atallah D, Le Bouedec G, et al. Laparoscopic radical hysterectomy for invasive cervical cancer: 8-year experience of a pilot study. Gynecol Oncol. 2003;91(3):534-539. doi: 10.1016/j.ygyno.2003.08.035
- Kucukmetin A, Biliatis I, Naik R, Bryant A. Laparoscopically assisted radical vaginal hysterectomy versus radical abdominal hysterectomy for the treatment of early cervical cancer. Cochrane Database Syst Rev. 2013;2013(10):CD006651. doi: 10.1002/14651858.CD006651.pub3
- Jin YM, Liu SS, Chen J, Chen YN, Ren CC. Robotic radical hysterectomy is superior to laparoscopic radical hysterectomy and open radical hysterectomy in the treatment of cervical cancer. PLoS One. 2018;13(3):e0193033. doi: 10.1371/journal.pone.0193033
- Ramirez PT, Frumovitz M, Pareja R, et al. Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer. N Engl J Med. 2018;379(20):1895-1904. doi: 10.1056/NEJMoa1806395
- Cibula D, Raspollini MR, Planchamp F, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with cervical cancer - Update 2023. Int J Gynecol Cancer. 2023;33(5):649-666. doi: 10.1136/ijgc-2023-004429
- Plante M, Kwon JS, Ferguson S, et al. Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer. N Engl J Med. 2024;390(9):819-829. doi: 10.1056/NEJMoa2308900
- Wang XJ, Fang F, Li YF. Sentinel-lymph-node procedures in early stage cervical cancer: a systematic review and meta-analysis. Med Oncol. 2015;32(1):385. doi: 10.1007/s12032-014-0385-x
- Ayoub NL, Shin R, Tseng J, Francoeur AA. Minimally invasive surgery in gynecologic oncology: a narrative review of controversies and clinical implications. Gynecol Pelvic Med. 2025;8:24. doi: 10.21037/gpm-25-19
- Santia MC, Meschini T, Hsu HC, et al. Current Updates on Surgical Management of Patients with Early-Stage Cervical Cancer. Cancers (Basel). 2025;17(13):2259. doi: 10.3390/cancers17132259
- Santia MC, Morante-Caicedo C, Pineros Castillo WA, et al. Surgical de-escalation of cervical cancer treatment in limited-resource settings. Int J Gynecol Cancer. 2026:102862. doi: 10.1016/j.ijgc.2025.102862
- Danisch M, Postl M, Bartl T, et al. Novel Treatment Concepts for Cervical Cancer-Moving Towards Personalized Therapy. J Pers Med. 2025;15(11):523. doi: 10.3390/jpm15110523
- Yordanov A, Tsoneva E, Hasan I, Kostov S. Sentinel Lymph Node Dissection-Novelty, Trend, or a Paradigm Shift in Surgical Decision-Making for Early Cervical Cancer? Medicina (Kaunas). 2025;61(9):1660. doi: 10.3390/medicina61091660
- Xiao C, Zeng S, Li L, Wang R, Xiao X. Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity. Front Oncol. 2026;16:1765529. doi: 10.3389/fonc.2026.1765529
- Nguy L, Avila M. Fertility-Sparing Cervical Cancer: Procedures and Outcomes. J Gynecol Surg. 2026;42(1):21-27. doi: 10.1177/10424067251407838
- Querleu D, Morrow CP. Classification of radical hysterectomy. Lancet Oncol. 2008;9(3):297-303. doi: 10.1016/S1470-2045(08)70074-3
- Querleu D, Cibula D, Abu-Rustum NR. 2017 Update on the Querleu-Morrow Classification of Radical Hysterectomy. Ann Surg Oncol. 2017;24(11):3406-3412. doi: 10.1245/s10434-017-6031-z
- Raspagliesi F, Ditto A, Fontanelli R, et al. Type II versus Type III nerve-sparing radical hysterectomy: comparison of lower urinary tract dysfunctions. Gynecol Oncol. 2006;102(2):256-262. doi: 10.1016/j.ygyno.2005.12.014
- Maneschi F, Ianiri P, Sarno M, Gagliardi F, Panici PB. Nerve-sparing class III-IV radical hysterectomy: urodynamic study and surgical technique. Int J Gynecol Cancer. 2012;22(4):675-680. doi: 10.1097/IGC.0b013e3182473256
- Long Y, Yao DS, Pan XW, Ou TY. Clinical efficacy and safety of nerve-sparing radical hysterectomy for cervical cancer: a systematic review and meta-analysis. PLoS One. 2014;9(4):e94116. doi: 10.1371/journal.pone.0094116
- Laterza RM, Sievert KD, de Ridder D, et al. Bladder function after radical hysterectomy for cervical cancer. Neurourol Urodyn. 2015;34(4):309-315. doi: 10.1002/nau.22570
- Society of Gynecologic Oncology. Notice to SGO Members: Emerging Data on the Surgical Approach for Radical Hysterectomy in the Treatment of Women with Cervical Cancer. Society of Gynecologic Oncology. Updated November 13, 2018. Accessed June 7, 2026. https://www.sgo.org/resources/notice-to-sgo-members-emerging-data-on-the-surgical-approach-for-radical-hysterectomy-in-the-treatment-of-women-with-cervical-cancer/
- National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Cervical Cancer. Clinical Practice Guideline. 2025. NCCN Guidelines®. Updated November 10, 2025. Accessed May 15, 2026. https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf
- Levin G, Ramirez PT, Wright JD, et al. Approach to radical hysterectomy for cervical cancer after the Laparoscopic Approach to Cervical Cancer trial and associated complications: a National Surgical Quality Improvement Program study. Am J Obstet Gynecol. 2025;232(2):208.e1-208.e11. doi: 10.1016/j.ajog.2024.08.008
- Armbrust R, Chen F, Richter R, et al. Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11. Sci Rep. 2021;11(1):9774. doi: 10.1038/s41598-021-89071-0
- Melamed A, Margul DJ, Chen L, et al. Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer. N Engl J Med. 2018;379(20):1905-1914. doi: 10.1056/NEJMoa1804923
- Nitecki R, Ramirez PT, Frumovitz M, et al. Survival After Minimally Invasive vs Open Radical Hysterectomy for Early-Stage Cervical Cancer: A Systematic Review and Meta-analysis. JAMA Oncol. 2020;6(7):1019-1027. doi: 10.1001/jamaoncol.2020.1694
- Chiva L, Zanagnolo V, Querleu D, et al. SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer. Int J Gynecol Cancer. 2020;30(9):1269-1277. doi: 10.1136/ijgc-2020-001506
- Kanao H, Matsuo K, Aoki Y, et al. Feasibility and outcome of total laparoscopic radical hysterectomy with no-look no-touch technique for FIGO IB1 cervical cancer. J Gynecol Oncol. 2019;30(3):e71. doi: 10.3802/jgo.2019.30.e71
- Kim SI, Lee M, Lee S, et al. Impact of laparoscopic radical hysterectomy on survival outcome in patients with FIGO stage IB cervical cancer: A matching study of two institutional hospitals in Korea. Gynecol Oncol. 2019;155(1):75-82. doi: 10.1016/j.ygyno.2019.07.019
- Song YL, Li RZ, Feng BJ, et al. Survival after minimally invasive radical hysterectomy with protective colpotomy for early-stage cervical cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 2024;50(4):108240. doi: 10.1016/j.ejso.2024.108240
- Li Y, Zhao J, Ding X, et al. Oncologic Outcomes of Laparoscopic Radical Hysterectomy Incorporating Modified Tumor-Free Techniques. Obstet Gynecol. 2025;145(2):134-143. doi: 10.1097/AOG.0000000000005805
- Hu M, Ji L, Jin L, Shao M. Minimally invasive surgery for cervical cancer. Oncol Lett. 2025;29(6):281. doi: 10.3892/ol.2025.15027
- Li RZ, Sun LF, Li R, Wang HJ. Survival after minimally invasive radical hysterectomy without using uterine manipulator for early-stage cervical cancer: A systematic review and meta-analysis. BJOG. 2023;130(2):176-183. doi: 10.1111/1471-0528.17339
- Bao W, He X, Huang Y, Xing A, Li Z. Effect of uterine manipulator on stage IB1 to IIA1 cervical cancer: A retrospective cohort study. Gynecol Oncol. 2026;204:27-36. doi: 10.1016/j.ygyno.2025.10.037
- Polen-De CL, Giannini A, Langstraat CL, et al. Effect of conization, manipulator use, and their interaction on recurrence after radical hysterectomy for cervical cancer: A multicenter retrospective analysis. Gynecol Oncol. 2025;201:33-39. doi: 10.1016/j.ygyno.2025.08.005
- Ferrero S, Barra F, Vellone VG. Beyond LACC: Is There Still a Role for Minimally Invasive Surgery in Early-Stage Cervical Cancer? Clin Exp Obstet Gynecol. 2026;53(8):53908. doi: 10.31083/ceog53908
- Falconer H, Palsdottir K, Stalberg K, et al. Robot-assisted approach to cervical cancer (RACC): an international multi-center, open-label randomized controlled trial. Int J Gynecol Cancer. 2019;29(6):1072-1076. doi: 10.1136/ijgc-2019-000558
- Leitao MM Jr, Bixel KL, Chase DM, et al. ROCC/GOG-3043: a randomized controlled trial of robotic versus open surgery for early-stage cervical cancer. Int J Gynecol Cancer. 2025;35(7):101760. doi: 10.1016/j.ijgc.2025.101760
- Tewari KS. Cervical Cancer. N Engl J Med. 2025;392(1):56-71. doi: 10.1056/NEJMra2404457
- Kampers J, Gerhardt E, Sibbertsen P, et al. Protective operative techniques in radical hysterectomy in early cervical carcinoma and their influence on disease-free and overall survival: a systematic review and meta-analysis of risk groups. Arch Gynecol Obstet. 2021;304(3):577-587. doi: 10.1007/s00404-021-06082-y
- Ramirez PT, Robledo KP, Frumovitz M, et al. LACC Trial: Final Analysis on Overall Survival Comparing Open Versus Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer. J Clin Oncol. 2024;42(23):2741-2746. doi: 10.1200/JCO.23.02335
- Manzour N, Chiva L, Zanagnolo V, et al. SUCCOR 10 years: a decade's perspective on radical hysterectomy outcomes in cervical cancer. Int J Gynecol Cancer. 2025;35(5):101690. doi: 10.1016/j.ijgc.2025.101690
- Zhang C, Tian W, Zhou X, et al. Outcomes of Laparoscopic Radical Hysterectomy in Ia1-Ib1 Cervical Cancer Patients: A Multi-Center Study with 10 Years' Experiences in the Real World. Ann Surg Oncol. 2025;32(3):2213-2222. doi: 10.1245/s10434-024-16637-3
- Covens A, Rosen B, Murphy J, et al. How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol. 2002;84(1):145-149. doi: 10.1006/gyno.2001.6493
- Baiocchi G, de Brot L, Faloppa CC, et al. Is parametrectomy always necessary in early-stage cervical cancer? Gynecol Oncol. 2017;146(1):16-19. doi: 10.1016/j.ygyno.2017.03.514
- Vanichtantikul A, Tantbirojn P, Manchana T. Parametrial involvement in women with low-risk, early-stage cervical cancer. Eur J Cancer Care (Engl). 2017;26(5). doi: 10.1111/ecc.12583
- Tarney CM, Tian C, Randall LM, et al. Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy. JAMA Netw Open. 2025;8(5):e2510717. doi: 10.1001/jamanetworkopen.2025.10717
- Ramirez PT, Pareja R, Rendon GJ, Millan C, Frumovitz M, Schmeler KM. Management of low-risk early-stage cervical cancer: should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care? Gynecol Oncol. 2014;132(1):254-259. doi: 10.1016/j.ygyno.2013.09.004
- Kietpeerakool C, Rattanakanokchai S, Shawky M, Morrison J. Simple hysterectomy with pelvic lymphadenectomy versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2-IB1 cervical cancer. Cochrane Database Syst Rev. 2025;10(10):CD012335. doi: 10.1002/14651858.CD012335.pub2
- Rob L, Halaska M, Robova H. Nerve-sparing and individually tailored surgery for cervical cancer. Lancet Oncol. 2010;11(3):292-301. doi: 10.1016/S1470-2045(09)70191-3
- Kietpeerakool C, Aue-Aungkul A, Galaal K, Ngamjarus C, Lumbiganon P. Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa). Cochrane Database Syst Rev. 2019;2(2):CD012828. doi: 10.1002/14651858.CD012828.pub2
- Marucci da Silva GF, Pilger TL, Candido Dos Reis FJ. Incidence of urologic co-morbidities after abdominal radical hysterectomy: a systematic review of clinical trials. Int J Gynecol Cancer. 2026;36(1):102722. doi: 10.1016/j.ijgc.2025.102722
- Cibula D, Velechovska P, Slama J, et al. Late morbidity following nerve-sparing radical hysterectomy. Gynecol Oncol. 2010;116(3):506-511. doi: 10.1016/j.ygyno.2009.10.061
- Pieterse QD, Kenter GG, Maas CP, et al. Self-reported sexual, bowel and bladder function in cervical cancer patients following different treatment modalities: longitudinal prospective cohort study. Int J Gynecol Cancer. 2013;23(9):1717-1725. doi: 10.1097/IGC.0b013e3182a80a65
- Pieterse QD, Maas CP, ter Kuile MM, et al. An observational longitudinal study to evaluate miction, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer. Int J Gynecol Cancer. 2006;16(3):1119-1129. doi: 10.1111/j.1525-1438.2006.00461.x
- Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019;393(10167):169-182. doi: 10.1016/S0140-6736(18)32470-X
- Schmeler KM, Frumovitz M, Ramirez PT. Conservative management of early stage cervical cancer: is there a role for less radical surgery? Gynecol Oncol. 2011;120(3):321-325. doi: 10.1016/j.ygyno.2010.12.352
- O'Donnell R, Naik R. Conservative (non-radical) surgery for stage IB1 cervical cancer. Best Pract Res Clin Obstet Gynaecol. 2021;75:54-64. doi: 10.1016/j.bpobgyn.2021.05.002
- Schmeler KM, Pareja R, Lopez Blanco A, et al. ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer. Int J Gynecol Cancer. 2021;31(10):1317-1325. doi: 10.1136/ijgc-2021-002921
- Carter J, Huang HQ, Monk BJ, et al. Evaluation of physical function and quality of life before and after nonradical surgical therapy for stage IA1 and IA2-IB1 cervical cancer (GOG-0278). Gynecol Oncol. 2025;195:50-58. doi: 10.1016/j.ygyno.2025.02.023
- Covens A, Huang HQ, Monk BJ, et al. Evaluation of efficacy and fertility after nonradical surgical therapy (extra fascial hysterectomy or cone biopsy, with pelvic lymphadenectomy) for stage IA1, IA2, and IB1 cervical cancer (GOG-0278). Gynecol Oncol. 2025;195:59-65. doi: 10.1016/j.ygyno.2025.03.005
- Ferguson SE, Brotto LA, Kwon J, et al. Sexual Health and Quality of Life in Patients With Low-Risk Early-Stage Cervical Cancer: Results From GCIG/CCTG CX.5/SHAPE Trial Comparing Simple Versus Radical Hysterectomy. J Clin Oncol. 2025;43(2):167-179. doi: 10.1200/JCO.24.00440
- Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191-e203. doi: 10.1016/S2214-109X(19)30482-6
- Dargent D, Martin X, Sacchetoni A, Mathevet P. Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients. Cancer. 2000;88(8):1877-1882.
- Dargent D, Brun JL, Roy M, Mathevet P, Remy I. La trachélectomie élargie. Une alternative à l'hystérectomie radicale dans le traitement des cancers infiltrants développés sur la lace externe du col utérin. JOBGYN. 1994;2:282-292.
- Smith ES, Moon AS, O'Hanlon R, et al. Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review. Obstet Gynecol. 2020;136(3):533-542. doi: 10.1097/AOG.0000000000003952
- Morice P, Maulard A, Scherier S, et al. Oncologic results of fertility sparing surgery of cervical cancer: An updated systematic review. Gynecol Oncol. 2022;165(1):169-183. doi: 10.1016/j.ygyno.2022.01.023
- Kim JH, Hwang WY, Choi CH, et al. Oncologic outcomes and the impact of minimally invasive surgery in early-stage cervical cancer patients undergoing radical trachelectomy: A retrospective multicenter cohort study from the Korean Gynecologic Oncology Group Study (KGOG 1048). Gynecol Oncol. 2026;208:113-121. doi: 10.1016/j.ygyno.2026.04.003
- Nezhat C, Roman RA, Rambhatla A, Nezhat F. Reproductive and oncologic outcomes after fertility-sparing surgery for early stage cervical cancer: a systematic review. Fertil Steril. 2020;113(4):685-703. doi: 10.1016/j.fertnstert.2020.02.003
- Kasuga Y, Hasegawa K, Hamuro A, et al. Pregnancy outcomes following radical trachelectomy for early-stage cervical cancer: A retrospective observational study in the Kanto area, Japan. Int J Gynaecol Obstet. 2024;164(1):108-114. doi: 10.1002/ijgo.14935
- Soltanizadeh S, Rosendahl M, Froding LP, Bjorn SF, Mosgaard BJ, Hogdall C. After Radical Trachelectomy: Reproductive and Obstetrical Outcomes of Fertility-Sparing Surgery for Cervical Cancer. Semin Reprod Med. 2025;43(1):11-15. doi: 10.1055/s-0045-1808092
- Li X, Li J, Jiang Z, et al. Oncological results and recurrent risk factors following abdominal radical trachelectomy: an updated series of 333 patients. BJOG. 2019;126(9):1169-1174. doi: 10.1111/1471-0528.15621
- Li X, Li J, Wen H, et al. The Survival Rate and Surgical Morbidity of Abdominal Radical Trachelectomy Versus Abdominal Radical Hysterectomy for Stage IB1 Cervical Cancer. Ann Surg Oncol. 2016;23(9):2953-2958. doi: 10.1245/s10434-016-5216-1
- van Kol KGG, Vergeldt TFM, Bekkers RLM. Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates. Gynecol Oncol. 2019;155(3):515-521. doi: 10.1016/j.ygyno.2019.09.025
- Feng Y, Shen Y, Huang H, et al. Neoadjuvant chemotherapy and individualized de-escalation surgery for fertility preservation in stage IB1-IIA2 cervical cancer: A multicenter prospective study (FIND study). J Clin Oncol. 2026;44(16_suppl):5533. doi: 10.1200/JCO.2026.44.16_suppl.5533
- Salvo G, Ramirez PT, Leitao MM, et al. Open vs minimally invasive radical trachelectomy in early-stage cervical cancer: International Radical Trachelectomy Assessment Study. Am J Obstet Gynecol. 2022;226(1):97.e1-97.e16. doi: 10.1016/j.ajog.2021.08.029
- Baiocchi G, Tsunoda AT, Guitmann G, et al. Brazilian Society of Surgical Oncology consensus on fertility-sparing surgery for cervical cancer. J Surg Oncol. 2022;126(1):37-47. doi: 10.1002/jso.26899
- Sidonie M, Elisabete G. Oncologic, pregnancy, and reproductive outcomes of fertility-sparing surgery in early-stage cervical cancer: a systematic review. Surg Oncol. 2026;66:102439. doi: 10.1016/j.suronc.2026.102439
- Viveros-Carreno D, Agusti N, Mora-Soto N, Wilke RN, Pareja R. De-escalation in definitive surgical management for cervical cancer. Int J Gynecol Cancer. 2025:102711. doi: 10.1016/j.ijgc.2025.102711
- Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri: 2021 update. Int J Gynaecol Obstet. 2021;155 Suppl 1(Suppl 1):28-44. doi: 10.1002/ijgo.13865
- Gien LT, Covens A. Lymph node assessment in cervical cancer: prognostic and therapeutic implications. J Surg Oncol. 2009;99(4):242-247. doi: 10.1002/jso.21199
- Cormier B, Diaz JP, Shih K, et al. Establishing a sentinel lymph node mapping algorithm for the treatment of early cervical cancer. Gynecol Oncol. 2011;122(2):275-280. doi: 10.1016/j.ygyno.2011.04.023
- Kadkhodayan S, Hasanzadeh M, Treglia G, et al. Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: a systematic review and meta-analysis of the pertinent literature. Eur J Surg Oncol. 2015;41(1):1-20. doi: 10.1016/j.ejso.2014.09.010
- Lecuru F, Mathevet P, Querleu D, et al. Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study. J Clin Oncol. 2011;29(13):1686-1691. doi: 10.1200/JCO.2010.32.0432
- Mathevet P, Lecuru F, Uzan C, et al. Sentinel lymph node biopsy and morbidity outcomes in early cervical cancer: Results of a multicentre randomised trial (SENTICOL-2). Eur J Cancer. 2021;148:307-315. doi: 10.1016/j.ejca.2021.02.009
- Favre G, Guani B, Balaya V, Magaud L, Lecuru F, Mathevet P. Sentinel Lymph-Node Biopsy in Early-Stage Cervical Cancer: The 4-Year Follow-Up Results of the Senticol 2 Trial. Front Oncol. 2020;10:621518. doi: 10.3389/fonc.2020.621518
- Cibula D, Marnitz S, Jarkovsky J, et al. Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international trial. Nat Cancer. 2025;6(9):1585-1594. doi: 10.1038/s43018-025-01016-y
- Tu H, Huang H, Li Y, et al. Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer. N Engl J Med. 2025;393(15):1463-1474. doi: 10.1056/NEJMoa2506267
- Tu H, Huang H, Li Y, et al. Sentinel lymph node biopsy versus pelvic lymphadenectomy in cervical cancer: The PHENIX trial. Meeting Abstract. J Clin Oncol. 2025;43(17_suppl):LBA5501. doi: 10.1200/JCO.2025.43.17_suppl.LBA5501
- Lecuru FR, McCormack M, Hillemanns P, et al. SENTICOL III: an international validation study of sentinel node biopsy in early cervical cancer. A GINECO, ENGOT, GCIG and multicenter study. Int J Gynecol Cancer. 2019;29(4):829-834. doi: 10.1136/ijgc-2019-000332
- Guani B, Dorez M, Magaud L, Buenerd A, Lecuru F, Mathevet P. Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial. Int J Gynecol Cancer. 2019;29(3):447-452. doi: 10.1136/ijgc-2018-000089
- Stolnicu S, Barsan I, Hoang L, et al. International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. Am J Surg Pathol. 2018;42(2):214-226. doi: 10.1097/PAS.0000000000000986
- WHO Classification of Tumours Editorial Board. WHO Classification of Tumours: Female Genital Tumours. 5th ed. Vol 4. Lyon, France: International Agency for Research on Cancer; 2020.
- Karamurzin YS, Kiyokawa T, Parkash V, et al. Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. Am J Surg Pathol. 2015;39(11):1449-1457. doi: 10.1097/PAS.0000000000000532
- Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C. The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology. 2013;266(3):717-740. doi: 10.1148/radiol.12120315
- Thomeer MG, Gerestein C, Spronk S, van Doorn HC, van der Ham E, Hunink MG. Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and meta-analysis. Eur Radiol. 2013;23(7):2005-2018. doi: 10.1007/s00330-013-2783-4
- Gupta A, Dagar G, Das SK, et al. Prognostic value of circulating HPV cell-free DNA in cervical cancer using liquid biopsy. Sci Rep. 2025;15(1):11480. doi: 10.1038/s41598-025-93152-9
- Green JA, Kirwan JM, Tierney JF, et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet. 2001;358(9284):781-786. doi: 10.1016/S0140-6736(01)05965-7
- Rydzewska L, Tierney J, Vale CL, Symonds PR. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database Syst Rev. 2012;12(12):CD007406. doi: 10.1002/14651858.CD007406.pub3
- Kenter GG, Greggi S, Vergote I, et al. Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994. J Clin Oncol. 2023;41(32):5035-5043. doi: 10.1200/JCO.22.02852
- Gupta S, Maheshwari A, Parab P, et al. Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial. J Clin Oncol. 2018;36(16):1548-1555. doi: 10.1200/JCO.2017.75.9985
- Mauricio D, Zeybek B, Tymon-Rosario J, Harold J, Santin AD. Immunotherapy in Cervical Cancer. Curr Oncol Rep. 2021;23(6):61. doi: 10.1007/s11912-021-01052-8
- Ogasawara A, Hasegawa K. Recent advances in immunotherapy for cervical cancer. Int J Clin Oncol. 2025;30(3):434-448. doi: 10.1007/s10147-025-02699-0
- Kouhen F, El Ghanmi A, Inghaoun H, Miftah H, Ghazi B, Badou A. The promise of PD1/PDL1 targeted immunotherapy in locally advanced cervical cancer: a game-changer for patients outcome? Front Immunol. 2025;16:1573576. doi: 10.3389/fimmu.2025.1573576
