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Publication:

Surgical Technology International XVIII - Orhopaedic Surgery

Article title:

The Use of a Type-I Lyophilisate Collagen as an Osteoinductive Factor in Pseudarthroses of the Forearm

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Author(s)

M. Strassmair, M.D.
Director, Division of Hand Surgery
Department of Orthopaedic Surgery
Klinikum Starnberg
Starnberg, Germany

M.A. Mont, M.D.
Director, Center for Joint Preservation and
Reconstruction
Rubin Institute for Advanced Orthopedics
Sinai Hospital of Baltimore
Baltimore, Maryland, USA

T.M. Seyler, M.D.
Fellow, Center for Joint Preservation and
Reconstruction
Rubin Institute for Advanced Orthopedics
Sinai Hospital of Baltimore
Baltimore, Maryland, USA

H. Bosebeck, Ph.D.
Chief Scientist & Medical Affairs
Heraeus Medical
Wehrheim, Germany

D.R. Marker, B.S.
Medical Student
Department of Orthopaedic Surgery
Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA

D.M. LaPorte, M.D.
Assistant Professor
Department of Orthopaedic Surgery
Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA

Abstract

The purpose of this study was to assess the use of a novel bone void filler consisting of Type I collagen and various growth factors (VEGF, TGFß-1, TGFß-2, IGF-1, BMP-2, BMP-3, and BMP-7) and surgical fixation to treat diaphyseal forearm pseudarthroses. Eleven patients underwent an osteosynthesis procedure for isolated pseudarthrosis fractures of the forearm (six radial and five ulnar diaphysis). The mean duration between the initial failed surgical fixation and re-operation was 38 weeks. Radiographic signs of fracture healing after the application of the bone void filler were noted at a mean of 5 weeks, and complete fracture consolidation was achieved at a mean of 6 weeks. All patients demonstrated improved range of motion and grip strength. Additionally, all patients were pain-free by 6 weeks. The combination of a novel bovine bone-derived bone void filler and stable internal fixation led to union and rapid healing of forearm pseudarthroses.